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Author: Daniel Steinberg
ISBN : 0123739799
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Format: PDF, EPUB
Download for free books Free Download The Cholesterol Wars: The Skeptics vs the Preponderance of Evidence for everyone book 4shared, mediafire, hotfile, and mirror link
Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.
* Dr. Steinberg and his colleagues have published over 400 papers relating to lipid and lipoprotein metabolism and atherosclerosis reflecting the prominence these authors have in the community.
* Chronicles the miraculous power of the statins to prevent heart attacks and save lives, of great interest to the many manufacturers of these drugs
* Discusses new targets for intervention based on a better understanding of the molecular basis of atherosclerosis
Books with free ebook downloads available Free Download The Cholesterol Wars: The Skeptics vs the Preponderance of Evidence [Hardcover]
- Hardcover: 248 pages
- Publisher: Academic Press; 1 edition (September 24, 2007)
- Language: English
- ISBN-10: 0123739799
- ISBN-13: 978-0123739797
- Product Dimensions: 0.8 x 6.3 x 9 inches
- Shipping Weight: 1.3 pounds (View shipping rates and policies)
Free Download The Cholesterol Wars: The Skeptics vs the Preponderance of Evidence
This book contains a history of the research relating serum cholesterol to heart disease, from Anitschkow's rabbits to statin trials that reduced heart attacks and all-cause mortality. It exposes the error of those who claim that there is no evidence that saturated fat in the diet or LDL in the blood are related to heart disease. Whether you are convinced or not it's easy to see how reasonable people can hold Dr. Steinberg's position. Anyone who reads books by cholesterol skeptic also needs to read this book to hear the other side, presented by a real scientist. The following contains some evidence referenced in the book as well as additional evidence.
OBSERVATIONAL EVIDENCE
1. Atherosclerotic plaque contains a lot of cholesterol. In 1856 a German pathologist named Rudolf Virchow proposed that lipid accumulation in the artery wall caused atherosclerosis. In 1914 Nikolai Anitschkow also observed cholesterol crystals in advanced plaque in the aorta of cholesterol fed rabbits.
2. Michael Brown and Joseph Goldstein discovered that the number of functional LDL receptors on the surface of cells, especially liver cells determines the level of LDL in the blood. If the receptors are defective or too few in number, LDL builds up in the blood instead of being taken into the cells. Familial hypercholesterolemia (FH) is caused by the mutation of a single gene that does one thing; make LDL receptors. People with two copies of the mutation for FH have LDL levels 6 to 10 fold above normal and can have a heart attack as early as 18 months of age. People with one copy of the mutation have LDL levels 2 to 4 times above normal and develop clinical symptoms between the ages of 30 and 60. There is an obvious dose response relationship.
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