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(17 reviews)
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ISBN : 0471316180
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Format: PDF
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Responding to the immense changes due to recent development in research, Genomes is the first in a generation of molecular genetics books which combine standard molecular biology with more contemporary genomics. This book focuses on genome organization, expression, replication, and evolution, and includes a description of applications for molecular ecology and anthropology, reflecting the impact of genome biology on other fields of study.
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- Paperback: 608 pages
- Publisher: Wiley-Liss; 1 edition (May 26, 1999)
- Language: English
- ISBN-10: 0471316180
- ISBN-13: 978-0471316183
- Product Dimensions: 10.8 x 8.2 x 1.1 inches
- Shipping Weight: 2.9 pounds
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Because of the explosion of genetics research and technology in today's world, many textbooks and monographs on the subject have appeared. This book is certainly one of the finest of these, and emphasizes, as stated in the the preface, the major research issues in genetics, rather than issues that were important two decades ago. Genomes, not genes, the author states, should be the topic of primary focus. The more fundamental 'microscopic' processes such as DNA replication and mutation are studied in terms of their effects on the genome. This reflects the current move in genetics to find common ground between classical genetics and modern molecular genetics. Clearly the author is very excited about the developments in genetics that have taken place in the last decade, and this shows in his writing. The only major omission in the book is the lack of exercises; these are of upmost importance in the learning process. The book, written for beginning graduate students, could also be useful to mathematicians, physicists, or computer scientists who are moving into bioinformatics or computational biology. Some of the more interesting discussions in the book include: 1. The C-value paradox: The correlation between the complexity of an organism and the size of its genome is explained by a space optimization argument, i.e. the genomes of simpler organisms conserve space by packing the genes closer together. 2. Using DNA markers versus gene markers for genetic mapping. 3. Single nucleotide polymorphisms, oligonucleotide hybridization analysis, and their use in DNA chip technology and dynamic allele-specific hybridization. 4. The need for physical mapping techniques and the discussion on the discrepancies between genetic and physical maps of S. cerevisiae chromosome III. 5.
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