Rating:
(1 reviews)
Author: David A. Hopwood
ISBN : B005LQBV5G
New from $46.44
Format: PDF
Posts about Download The Book Free Download Streptomyces in Nature and Medicine:The Antibiotic Makers from mediafire, rapishare, and mirror link This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.Download latest books on mediafire and other links compilation Free Download Streptomyces in Nature and Medicine:The Antibiotic Makers
- File Size: 5872 KB
- Print Length: 272 pages
- Publisher: Oxford University Press, USA; 1 edition (January 8, 2007)
- Sold by: Amazon Digital Services, Inc.
- Language: English
- ASIN: B005LQBV5G
- Text-to-Speech: Not enabled
X-Ray for Textbooks:
- Lending: Enabled
- Amazon Best Sellers Rank: #1,485,231 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
Free Download Streptomyces in Nature and Medicine:The Antibiotic Makers
If you're looking for in-depth--history, not technical--information on this genera of bacteria, then this book is for you. Recommended... - lc
By Laurence Chalem